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Article

Polygenic risk for schizophrenia and subjective well-being in a general population sample.

Psychological medicine - 2 May 2025

Serimaa Oona, Keltikangas-Järvinen Liisa, Lyytikäinen Leo-Pekka, Hietala Jarmo, Sormunen Elina, Kähönen Mika, Raitakari Olli, Lehtimäki Terho, Saarinen Aino

Abstract excerpt

BACKGROUND: Previous evidence has reported associations of a polygenic risk score for schizophrenia (PRSSCZ) with negative developmental outcomes, such as psychiatric symptoms, adverse health behaviors, and reduced everyday functioning. We now investigated the relationship of PRSSCZ with subjectively experienced well-being. METHODS: Participants (n = 1866) came from the prospective population-based Young Finns...

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Identifiers

PMID: 40314168
DOI: 10.1017/S0033291725000911
PMCID: PMC12094622

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