Article

Identification of fibroblast-specific causal genes in atrial fibrillation through single-cell transcriptomics and Mendelian randomization

2026-06-04

Abstract excerpt

<title>Abstract</title> <p> Background Atrial fibrillation (AF) is the most common persistent arrhythmia. Atrial fibrosis driven by fibroblast activation is its key pathological basis, but AF pathogenic genes that specifically act on cardiac fibroblasts have not been fully elucidated at present. Methods This study integrated single-cell RNA sequencing (scRNA-seq) data of human atrial tissue and Mendelian rando...

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Literature Corpus work: e9e0d8b9-8c8a-5125-a36a-c6e4ef72b080
DOI: 10.21203/rs.3.rs-9796263/v1

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