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Article

Multiomics Analysis of Genetics and Epigenetics Reveals Pathogenesis and Therapeutic Targets for Atrial Fibrillation.

BioMed research international - 1 Jan 2021

Liu Li, Huang Jianjun, Wei Baomin, Mo Jianjiao, Wei Qinjiang, Chen Chengcai, Yan Wei, Huang Xiannan, He Fengzhen, Qin Lingling, Huang Hehua, Li Xue, Pan Xingshou

Abstract excerpt

OBJECTIVE: This study is aimed at understanding the molecular mechanisms and exploring potential therapeutic targets for atrial fibrillation (AF) by multiomics analysis. METHODS: Transcriptomics and methylation data of AF patients were retrieved from the Gene Expression Omnibus (GEO). Differentially expressed genes (DEGs) and differentially methylated sites between AF and normal samples were screened. Then,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33834070
DOI: 10.1155/2021/6644827
PMCID: PMC8018871

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