Integration of transcriptome and mendelian randomization analyses to explore the molecular mechanisms of atrial fibrillation.

Abstract excerpt

BACKGROUND: Atrial fibrillation (AF) is a prevalent arrhythmia associated with significant adverse outcomes and elevated mortality rates, though its underlying molecular mechanisms remain poorly understood. This study sought to identify key genes linked to AF through the integration of transcriptome analysis and Mendelian randomization (MR), supplemented by bioinformatics. METHODS: Differentially expressed genes...

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