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Article

Single-Cell Transcriptomics and Mendelian Randomization Analysis Reveal Key Genes in Atrial Fibrillation.

Journal of cardiovascular electrophysiology - 1 Sept 2026

Chen Xiangpeng, Chen Hongquan, Xu Shiguang, Wang Shumin, Wang Huishan, Meng Hao

Abstract excerpt

BACKGROUND: Atrial fibrillation (AF) is one of the most common cardiac arrhythmias. It reduces quality of life and increases the risk of complications such as stroke. Although progress has been made in understanding its pathogenesis, the key cellular subtypes and therapeutic targets remain unclear. METHODS: We applied single-cell transcriptomics to identify critical cellular subtypes in AF. High-dimensional...

Read the complete abstract on PubMed

Topics

Atrial Fibrillation
Mendelian Randomization Analysis
Humans
Genetic Predisposition to Disease
Single-Cell Gene Expression Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Transcriptome

Single-Cell Analysis

Macrophages

Gene Regulatory Networks

Phenotype

Gene Expression Profiling

Source

Open in PubMed Open full text

Identifiers

PMID: 42378484
DOI: 10.1111/jce.70432
PMCID: PMC13576619

Genes

RSRC2
SPP1
VAMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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