Article
Identification of biomarkers and pathways to identify novel therapeutic targets in Alzheimer’s disease: Insights from a systems biomedicine perspective
2018-11-29
Abstract excerpt
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. However, there are no peripheral biomarkers available that can detect AD onset. This study aimed to identify such AD biomarkers through an integrative analysis of blood cell gene expression data. We used two microarray datasets (GSE4226 and GSE4229) comp...
Topics
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- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- GDF15 and Related Biomarkers
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
Identifiers and source
- Literature Corpus work
- 2d8e609d-877c-57a8-9700-69fc115cc503
- DOI
- 10.1101/481879
