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Article

Hydrogel microtumor arrays of patient melanoma recapitulate phenotypes and drug sensitivity.

Biomaterials advances - 1 Nov 2026

Liu Yiling, Pawlush Matthew L, Gleba Justyna J, Lambert Ella G, Williams Caitlin E, Stenzel Martina H, Copland John A, Kilian Kristopher A

Abstract excerpt

Patient-derived tumor xenograft (PDTX) models are considered the gold standard for preserving tumor heterogeneity and recapitulating patient drug responses, yet their use is limited by high cost, long timelines, and variable engraftment success. Here, we present the application of a soft lithography patterned polyacrylamide microtumor array platform designed to mimic biophysical aspects of the melanoma tumor...

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Identifiers

PMID: 42330796
DOI: 10.1016/j.bioadv.2026.215015

Genes

ABCB5
BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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