Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor-on-chip platforms for transport phenotyping: decoding CAF-driven barriers to drug delivery.

Lab on a chip - 22 Apr 2026

Le Manach Doriane, Senez Vincent, Nees Matthias

Abstract excerpt

Physical barriers within solid tumors constitute a fundamental but often overlooked mechanism of therapeutic resistance, contributing to the poor success rate of cancer drug translation. Therapeutic molecules often fail to reach their intended targets due to mass-transport limitations imposed by the remodeled, spatially heterogeneous tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) drive dynamic...

Topics

Join the communities discussing this publication.

Antineoplastic Agents
Biological Transport
Cancer-Associated Fibroblasts
Drug Delivery Systems
Extracellular Matrix

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lab-On-A-Chip Devices

Microfluidic Analytical Techniques

Tumor Microenvironment

Source

Identifiers

PMID: 41972308
DOI: 10.1039/d5lc01131k

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor-on-chip platforms for transport phenotyping: decoding CAF-driven barriers to drug delivery.PMID 41972308Read ↗

Multicompartmentalized Microvascularized Tumor-on-a-Chip to Study Tumor-Stroma Interactions and Drug Resistance in Ovarian CancerSemantic proximity Read ↗

Microfluidic Platform for Drug Response Profiling in NSCLC Patient-Derived OrganoidsSemantic proximity Read ↗

A Human Organotypic Microfluidic Tumor Model Permits Investigation of the Interplay between Patient-Derived Fibroblasts and Breast Cancer CellsSemantic proximity Read ↗

Multicompartmentalized microvascularized tumor-on-a-chip to study tumor-stroma interactions and drug resistance in ovarian cancerSemantic proximity Read ↗

The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid TumorsSemantic proximity Read ↗

Matrix composition modulates cancer cell phenotypes and secretions in a blood-brain barrier organ-on-a-chip model: Comparison of collagen and hyaluronic acid.Semantic proximity Read ↗

Tumoroid-on-a-Plate (ToP): Physiologically Relevant Cancer Model Generation and Therapeutic ScreeningSemantic proximity Read ↗

Microphysiological vascularized solid tumor model for drugs and cell therapies screeningSemantic proximity Read ↗

Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression.Semantic proximity Read ↗

Microfluidic cytometric analysis of cancer cell transportability and invasiveness.Semantic proximity Read ↗

Biophysical perspectives to understanding cancer-associated fibroblastsSemantic proximity Read ↗

An integrated microfluidic chip for the capture, migration and molecular phenotyping of single circulating tumor cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.