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Article

Microfluidic model with air-walls reveals fibroblasts and keratinocytes modulate melanoma cell phenotype, migration, and metabolism.

Lab on a chip - 21 Mar 2021

Ayuso Jose M, Sadangi Shreyans, Lares Marcos, Rehman Shujah, Humayun Mouhita, Denecke Kathryn M, Skala Melissa C, Beebe David J, Setaluri Vijayasaradhi

Abstract excerpt

Melanoma evolution is a complex process. The role epidermal keratinocytes and dermal fibroblasts play in this process and the mechanisms involved in tumor-stroma interactions remain poorly understood. Here, we used a microfluidic platform to evaluate the cross-talk between human primary melanoma cells, keratinocytes and dermal fibroblasts. The microfluidic device included multiple circular chambers separated by a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33533390
DOI: 10.1039/d0lc00988a
PMCID: PMC7990711

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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