PROK1 Induces Macrophage M2 Phenotype Conversion to Promote Pancreatic Cancer Progression by Activating the PI3K/AKT Pathway Via Interacting with PROKR2.

doi:10.1007/s12010-026-05772-0

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Article

PROK1 Induces Macrophage M2 Phenotype Conversion to Promote Pancreatic Cancer Progression by Activating the PI3K/AKT Pathway Via Interacting with PROKR2.

Applied biochemistry and biotechnology - 1 Oct 2026

Ma Lan, Yan Xiaogang, Liu Di, Bu Wenping, Kang Fuping, Hui Yongfeng, Song Jianjun, Wang Feng

Abstract excerpt

The impact and mechanisms of PROK1 on macrophages in pancreatic cancer (PC) progression was investigated. PROK1 and PROKR2 expression in PC patients were detected by immunohistochemistry and Western blot. TIMER database analyzed correlation between PROK1/PROKR2 and macrophage infiltration in PC. PROK1 influence on macrophage M2 phenotypic conversion and PI3K/AKT pathway activity were investigated by detecting...

Read the complete abstract on PubMed

Topics

Humans
Proto-Oncogene Proteins c-akt
Phosphatidylinositol 3-Kinases
Macrophages
Animals
Pancreatic Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mice

Signal Transduction

Male

Female

Receptors, G-Protein-Coupled

Disease Progression

Cell Line, Tumor

Phenotype

Middle Aged

Mice, Nude

Source

Open in PubMed

Identifiers

PMID: 42329572
DOI: 10.1007/s12010-026-05772-0

Genes

PROK1
PROKR2
PC
CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

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