Article
VDR promotes pancreatic cancer progression in vivo by activating CCL20-mediated M2 polarization of tumor associated macrophage.
Cell communication and signaling : CCS - 10 Apr 2024
Li Hengzhen, Ruan Yuli, Liu Chao, Fan Xiaona, Yao Yuanfei, Dai Yisheng, Song Yushuai, Jiang Dan, Sun Ning, Jiao Guangtao, Chen Zhuo, Fan Shiheng, Meng Fanfei, Yang Huike, Zhang Yanqiao, Li Zhiwei
Abstract excerpt
BACKGROUND: Activation of VDR pathway was a promising anti-tumor therapy strategy. However, numerous clinical studies have demonstrated the effect of activating VDR is limited, which indicates that VDR plays a complex role in vivos. METHODS: We analyzed the TCGA database to examine the association between VDR expression and immune cell infiltration in pancreatic adenocarcinoma (PAAD). Western blot, ELISA, ChIP,...
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