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Tumour‐educated macrophages display a mixed polarisation and enhance pancreatic cancer cell invasion

25 Mar 2014

Abstract excerpt

At the time of diagnosis, almost 80% of pancreatic cancer patients present with new-onset type 2 diabetes (T2D) or impaired glucose tolerance. T2D and pancreatic cancer are both associated with low-grade inflammation. Tumour-associated macrophages (TAMs) have a key role in cancer-related inflammation, immune escape, matrix remodelling and metastasis. In this study, the interplay between tumour cells and immune...

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PMID: 24662521
DOI: 10.1038/icb.2014.22

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