Article
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
Nature medicine - 1 Sept 2015
Li Yun R, Li Jin, Zhao Sihai D, Bradfield Jonathan P, Mentch Frank D, Maggadottir S Melkorka, Hou Cuiping, Abrams Debra J, Chang Diana, Gao Feng, Guo Yiran, Wei Zhi, Connolly John J, Cardinale Christopher J, Bakay Marina, Glessner Joseph T, Li Dong, Kao Charlly, Thomas Kelly A, Qiu Haijun, Chiavacci Rosetta M, Kim Cecilia E, Wang Fengxiang, Snyder James, Richie Marylyn D, Flatø Berit, Førre Øystein, Denson Lee A, Thompson Susan D, Becker Mara L, Guthery Stephen L, Latiano Anna, Perez Elena, Resnick Elena, Russell Richard K, Wilson David C, Silverberg Mark S, Annese Vito, Lie Benedicte A, Punaro Marilynn, Dubinsky Marla C, Monos Dimitri S, Strisciuglio Caterina, Staiano Annamaria, Miele Erasmo, Kugathasan Subra, Ellis Justine A, Munro Jane E, Sullivan Kathleen E, Wise Carol A, Chapel Helen, Cunningham-Rundles Charlotte, Grant Struan F A, Orange Jordan S, Sleiman Patrick M A, Behrens Edward M, Griffiths Anne M, Satsangi Jack, Finkel Terri H, Keinan Alon, Prak Eline T Luning, Polychronakos Constantin, Baldassano Robert N, Li Hongzhe, Keating Brendan J, Hakonarson Hakon
Abstract excerpt
Genome-wide association studies (GWASs) have identified hundreds of susceptibility genes, including shared associations across clinically distinct autoimmune diseases. We performed an inverse χ(2) meta-analysis across ten pediatric-age-of-onset autoimmune diseases (pAIDs) in a case-control study including more than 6,035 cases and 10,718 shared population-based controls. We identified 27 genome-wide significant...
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