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Article

PheWAS and cross-disorder analysis reveal genetic architecture, pleiotropic loci and phenotypic correlations across 11 autoimmune disorders.

Frontiers in immunology - 1 Jan 2023

Topaloudi Apostolia, Jain Pritesh, Martinez Melanie B, Bryant Josephine K, Reynolds Grace, Zagoriti Zoi, Lagoumintzis George, Zamba-Papanicolaou Eleni, Tzartos John, Poulas Konstantinos, Kleopa Kleopas A, Tzartos Socrates, Georgitsi Marianthi, Drineas Petros, Paschou Peristera

Abstract excerpt

Introduction: Autoimmune disorders (ADs) are a group of about 80 disorders that occur when self-attacking autoantibodies are produced due to failure in the self-tolerance mechanisms. ADs are polygenic disorders and associations with genes both in the human leukocyte antigen (HLA) region and outside of it have been described. Previous studies have shown that they are highly comorbid with shared genetic risk...

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Autoimmune Diseases
Diabetes Mellitus, Type 1
HLA Antigens
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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Identifiers

PMID: 37809097
DOI: 10.3389/fimmu.2023.1147573
PMCID: PMC10552152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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