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Article

p27 Expression in Wild-Type KRAS Colon Cancer.

Journal of cellular and molecular medicine - 1 Jun 2026

Marinović Sonja, Paladin Iva, Škrtić Anita, Ivković Tina Catela, Verbanac Donatella, Kapitanović Sanja

Abstract excerpt

p27, a cyclin-dependent kinase inhibitor, functions as a tumour suppressor in the nucleus but may acquire oncogenic properties when mislocalized to the cytoplasm. While KRAS mutations can induce p27 phosphorylation and cytoplasmic retention, the regulation and significance of p27 expression in wild-type (WT) KRAS colorectal cancer (CRC) remain unclear. This study investigated the relationship between WT KRAS...

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Topics

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Share to Aged
Share to Colonic Neoplasms
Share to Cyclin-Dependent Kinase Inhibitor p27

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoplasm

Share to Gene Expression Regulation, Neoplastic

Share to MicroRNAs

Share to Polymorphism, Single Nucleotide

Share to Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 42324979
DOI: 10.1111/jcmm.71248
PMCID: PMC13284544

Genes

KRAS
CDKN1B

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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