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Article

p27: A Barometer of Signaling Deregulation and Potential Predictor of Response to Targeted Therapies

22 Oct 2010

Abstract excerpt

Phosphorylation of the cyclin-dependent kinase inhibitor p27 by upstream mitogenic signaling pathways regulates its stability, localization, and biological function. In human cancers, loss of the antiproliferative action of p27 can arise through reduced protein levels and/or cytoplasmic mislocalization, leading to increased cell proliferation and/or cell migration, respectively. Reduced p27 expression levels and...

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PMID: 20966355
DOI: 10.1158/1078-0432.ccr-10-0752

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