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LncRNA LIMp27 Regulates the DNA Damage Response through p27 in p53‐Defective Cancer Cells

13 Jan 2023

Abstract excerpt

P53 inactivation occurs in about 50% of human cancers, where p53-driven p21 activity is devoid and p27 becomes essential for the establishment of the G1/S checkpoint upon DNA damage. Here, this work shows that the E2F1-responsive lncRNA LIMp27 selectively represses p27 expression and contributes to proliferation, tumorigenicity, and treatment resistance in p53-defective colon adenocarcinoma (COAD) cells. LIMp27...

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PMID: 36638271
DOI: 10.1002/advs.202204599

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