Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Predicting the Impact of Deleterious Single-Nucleotide Polymorphisms in the p47ING1a Isoform of Human ING1 Gene.

Genetics research - 1 Jan 2026

Rafi Md Oliullah, Sarker Md Takim, Sheikh Mohammad Ashik, Das Sowmitro, Halder Sajal Kumar, Islam Md Ashiqul

Abstract excerpt

PURPOSE: The p47ING1a isoform of the ING1 tumor suppressor regulates cellular senescence through Rb-dependent pathways via its plant homeodomain (PHD) zinc-finger, which recognizes the H3K4me3 histone mark. However, the mutational landscape of p47ING1a and the functional consequences of PHD-domain nonsynonymous single-nucleotide polymorphisms (nsSNPs) remain poorly characterized. This study aimed to identify and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Models, Molecular
Share to Mutation, Missense

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Protein Isoforms

Source

Open in PubMed Open full text

Identifiers

PMID: 42322085
DOI: 10.1155/genr/2859448
PMCID: PMC13282558

Genes

ING1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Predicting the Impact of Deleterious Single-Nucleotide Polymorphisms in the p47ING1a Isoform of Human ING1 Gene.PMID 42322085Read ↗

Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor.Semantic proximity Read ↗

A comprehensive in silico investigation into the pathogenic SNPs in the RTEL1 gene and their biological consequences.Semantic proximity Read ↗

Investigation of deleterious effects of nsSNPs in the POT1 gene: a structural genomics‐based approach to understand the mechanism of cancer developmentSemantic proximity Read ↗

Identification of non-synonymous SNPs Impacting Structure and Function of MLH1 and NBN Proteins: A computational approach.Semantic proximity Read ↗

Identification of non-synonymous SNPs affecting structure and function of MLH1 and NBN proteins: a computational approach.Semantic proximity Read ↗

Investigating single amino acid substitutions in PIM1 kinase: A structural genomics approach.Semantic proximity Read ↗

In silico analysis of deleterious SNPs of human MTUS1 gene and their impacts on subsequent protein structure and function.Semantic proximity Read ↗

Bioinformatic processing to identify single nucleotide polymorphism that potentially affect Ape1 function.Semantic proximity Read ↗

Computational Identification of Most Deleterious Missense Mutations in Human PD-1 Gene.Semantic proximity Read ↗

Scrutinizing Deleterious Nonsynonymous SNPs and Their Effect on Human POLD1 Gene.Semantic proximity Read ↗

Structural insights into the impacts of non-synonymous single nucleotide polymorphisms in CD274 gene on the PD-1/PD-L1 interaction: An in silico approach.Semantic proximity Read ↗

Identification of the SIRT1 gene's most harmful non-synonymous SNPs and their effects on functional and structural features-an in silico analysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.