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Article

Structural insights into the impacts of non-synonymous single nucleotide polymorphisms in CD274 gene on the PD-1/PD-L1 interaction: An in silico approach.

Biochemical and biophysical research communications - 10 Oct 2025

Alam Syed Sahajada Mahafujul, Samanta Arijit, Ali Safdar, Hoque Mehboob

Abstract excerpt

Programmed cell death ligand 1 (PD-L1) on tumor cells interacts with PD-1 of activated T cells causing immune evasion. Polymorphisms in CD274 gene encoding PD-L1 have been associated with several cancer types. In this study, various bioinformatics tools were employed to identify the most deleterious non-synonymous single nucleotide polymorphisms (nsSNPs) in CD274 gene that could alter the structure and function...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40983009
DOI: 10.1016/j.bbrc.2025.152679

Genes

CD274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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