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Article

Identification of non-synonymous SNPs affecting structure and function of MLH1 and NBN proteins: a computational approach.

Journal of applied genetics - 1 May 2026

Gund Vaishnavi, Sharma Siddharth, Chandan Swet, Garg Shashank, Singh Sidhartha

Abstract excerpt

The genes NBN and MLH1 are critical for DNA repair, and this study aimed to detect and predict the effects of pathogenic single nucleotide polymorphisms (SNPs) in their mRNA and protein sequences. An in silico analysis assessed the impact of SNPs on the physicochemical properties, structure, stability, and function of MLH1 and NBN proteins. Results revealed that some SNPs significantly alter protein stability,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40312597
DOI: 10.1007/s13353-025-00968-2

Genes

MLH1
NBN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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