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Article

Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor.

Journal of molecular biology - 4 Jul 2008

Peña P V, Hom R A, Hung T, Lin H, Kuo A J, Wong R P C, Subach O M, Champagne K S, Zhao R, Verkhusha V V, Li G, Gozani O, Kutateladze T G

Abstract excerpt

Inhibitor of growth 1 (ING1) is implicated in oncogenesis, DNA damage repair, and apoptosis. Mutations within the ING1 gene and altered expression levels of ING1 are found in multiple human cancers. Here, we show that both DNA repair and apoptotic activities of ING1 require the interaction of the...

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Source

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Identifiers

PMID: 18533182
DOI: 10.1016/j.jmb.2008.04.061
PMCID: PMC2576750

Genes

ING1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18533182-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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