Pathway information on methylation analysis using deep neural network (PROMINENT): An interpretable deep learning method with pathway prior for phenotype prediction using gene-level DNA methylation.

Abstract excerpt

BACKGROUND: DNA methylation is a key epigenetic marker that influences gene expression and phenotype regulation, and is affected by both genetic and environmental factors. Traditional linear regression methods such as elastic nets have been employed to assess the cumulative effects of multiple DNA methylation markers on phenotypes. However, these methods often fail to capture the complex nonlinear nature of the...

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