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Article

Association of Cathepsin Proteins with Alzheimer's Disease Risk: An Integrated Observational and Genetic Analysis.

Neuromolecular medicine - 18 Jun 2026

Zhang Qianlong, Li Qingyang, Ai Zisheng, Li Fei, Wang Yi, Zhou Wei

Abstract excerpt

Alzheimer's disease (AD) involves complex lysosomal proteolytic dysfunction, but the specific roles of cathepsin family proteins remain unclear. This study aimed to systematically evaluate the association of cathepsins with AD risk and to explore underlying mechanistic pathways integrating neuroimaging, cognitive, and genetic evidence. We analyzed data from 52,988 UK Biobank participants. Plasma levels of 11...

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Identifiers

PMID: 42315799
DOI: 10.1007/s12017-026-08933-w

Genes

CTSL
APOE
ZNF285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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