Connecting dementia risk loci to the CSF proteome identifies pathophysiological leads for dementia.

doi:10.1093/brain/awae090

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Connecting dementia risk loci to the CSF proteome identifies pathophysiological leads for dementia.

Brain : a journal of neurology - 3 Oct 2024

Reus Lianne M, Jansen Iris E, Tijms Betty M, Visser Pieter Jelle, Tesi Niccoló, van der Lee Sven J, Vermunt Lisa, Peeters Carel F W, De Groot Lisa A, Hok-A-Hin Yanaika S, Chen-Plotkin Alice, Irwin David J, Hu William T, Meeter Lieke H, van Swieten John C, Holstege Henne, Hulsman Marc, Lemstra Afina W, Pijnenburg Yolande A L, van der Flier Wiesje M, Teunissen Charlotte E, Del Campo Milan Marta

Abstract excerpt

Genome-wide association studies have successfully identified many genetic risk loci for dementia, but exact biological mechanisms through which genetic risk factors contribute to dementia remains unclear. Integrating CSF proteomic data with dementia risk loci could reveal intermediate molecular pathways connecting genetic variance to the development of dementia. We tested to what extent effects of known dementia...

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Identifiers

PMID: 38527854
DOI: 10.1093/brain/awae090
PMCID: PMC11449142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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