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Article

Genetic colocalization of cathepsins H, D, and L1 with Alzheimer's disease: Implications for biomarker and therapeutic target discovery.

Journal of Alzheimer's disease : JAD - 1 Mar 2025

Dong Yu-Ting, Luo Xiao, Zhang Li-Li, Gong Yi-Meng, Wang Dan, Zhong Dong-Ling, Li Yu-Xi, Ma Xiao-Min, Jin Rong-Jiang, Li Juan

Abstract excerpt

BackgroundCathepsins, a family of lysosomal proteases, have been implicated in Alzheimer's disease (AD) pathogenesis through their involvement in amyloid-β protein precursor processing and neuroinflammation. However, the specific roles of different cathepsins in AD remain unclear.ObjectiveThis study aimed to investigate the genetic associations and potential causal relationships between cathepsins and AD, using...

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PMID: 39982062
DOI: 10.1177/13872877251314058

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