Article
Genetic Insights Into the Role of Cathepsins in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis: Evidence From Mendelian Randomization Study.
Brain and behavior - 1 Jan 2025
Jiang Yanhong, Fan Wenhui, Li Yaxin, Xue Hua
Abstract excerpt
BACKGROUND: Previous studies have confirmed the significant role of cathepsins in the development of neurodegenerative diseases. We aimed to determine whether genetically predicted 10 cathepsins may have a causal effect on Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). METHODS: We conducted a two-sample bidirectional Mendelian randomization (MR) study using publicly...
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