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Article

Cathepsins and age-related macular degeneration: A Mendelian randomization study unveiling causal relationships.

Medicine - 9 May 2025

Han Xiaoyan, Hua Zhixiang, Chen Han, Yang Jin

Abstract excerpt

Age-related macular degeneration (AMD) is a leading cause of vision impairment and blindness in older adults, profoundly affecting millions of individuals worldwide. Cathepsins are a crucial class of proteolytic enzymes that participates in multiple biological process. However, the role of cathepsins in AMD still remains unclear. This study aims to probe into the causal relationship between cathepsins and AMD...

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Cathepsin B
Cathepsins
Genome-Wide Association Study
Macular Degeneration
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 40355192
DOI: 10.1097/MD.0000000000042357
PMCID: PMC12073853

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