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Article

Bidirectional causal association between cathepsins and neuropsychiatric disorders: univariate and multivariate Mendelian randomization study.

European archives of psychiatry and clinical neuroscience - 1 Jun 2026

Li Zeyang, Jia Lei, Huai Shengnan

Abstract excerpt

BACKGROUND: Neuropsychiatric disorders are among the most common diseases worldwide and are characterized by complex pathogenic mechanisms. Cathepsins (CTS) are crucially involved in the pathogenesis and treatment of numerous diseases. Increasing evidence suggests a relationship between cathepsins and neuropsychiatric disorders. However, the causal associations remain unclear. METHODS: We performed a...

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Identifiers

PMID: 41212305
DOI: 10.1007/s00406-025-02150-5

Genes

CTSH
CTSE
CTSF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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