Article
BMI-genome interactions regulate global gene expression with emphasis in brain and gut.
Cell genomics - 8 Jul 2026
Signer Rebecca, Seah Carina, Young Hannah, Retallick-Townsley Kayla, Ciarcia Julia, De Pins Agathe, Cote Alanna, Lee Seoyeon, Jia Meng, Johnson Jessica, Johnston Keira J A, Xu Jiayi, Brennand Kristen J, Huckins Laura M
Abstract excerpt
Genome-wide association studies identify single-nucleotide polymorphisms (SNPs) associated with disease in a population but do not reliably account for individual environmental effects, despite evidence that environment mediates SNP functional regulatory capacity. Body mass index (BMI) is associated with physiologic processes across disorders but hasn't been modeled as an environment for disease-associated SNPs....
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