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Article

Gene-environment interplay explaining individual variation in BMI outcomes: a systematic review and meta-analysis of studies using polygenic indices.

International journal of obesity (2005) - 1 Feb 2026

de Roo Marthe, Hartman Catharina A, Wiertsema Maria, Kretschmer Tina

Abstract excerpt

BACKGROUND: Genetic and environmental factors are both associated with weight outcomes, but it remains unclear to what extent environmental exposures are consistently associated beyond genetic predisposition, and to what extent they modify genetic risk. METHODS: We meta-analyzed evidence on gene-environment interplay and individual variation in BMI and related outcomes, focusing on peer-reviewed studies examining...

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PMID: 41318678
DOI: 10.1038/s41366-025-01957-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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