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Article

Analysis of caffeine and paraxanthine in human saliva with ultra-high-performance liquid chromatography for CYP1A2 phenotyping.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences - 15 Jul 2015

Jordan Nan Yeun, Mimpen Jolet Y, van den Bogaard Willie J M, Flesch Frits M, van de Meent Michiel H M, Torano Javier Sastre

Abstract excerpt

Cytochrome P450 1A2 (CYP1A2) plays an important role in drug metabolism. Caffeine (CAF) is converted into paraxanthine (PX) by this enzyme and is used as a xenobiotic substrate to determine the CYP1A2 phenotype in humans. A method for the quantification of CAF and PX in saliva was developed using liquid-liquid extraction with ethyl acetate and analysis with ultra-high-performance liquid chromatography. Peaks from...

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Identifiers

PMID: 26038236
DOI: 10.1016/j.jchromb.2015.05.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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