Article

Lipid dependence of connexin-32 gap junction channel conformations

2025-03-27

Abstract excerpt

Connexin gap junction channels (GJCs) are a family of proteins that connect the cytoplasms of two neighbouring cells and allow direct intercellular exchange of solutes smaller than ∼1 kDa, ensuring metabolic and electrical coupling of tissues. Connexin-32 (Cx32) GJCs mediate intercellular coupling in a variety of tissues, and specifically in the myelinating Schwann cells. Mutations in Cx32, such as W3S, are associ...

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Literature Corpus work: 55e0cb85-1736-5521-a8e4-50dab04bb3ae
DOI: 10.1101/2025.03.25.645310

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