Article
Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease.
The New England journal of medicine - 11 Jun 2026
Gharahdaghi Nima, Yeh Pai-Jui, Ceron-Gutierrez Lourdes, Griffin Helen, Gordon Hannah, Jayamanne Chamara, Fracchia Alice, Chong Amanda Y, Walsh Alissa, Brain Oliver, Baker Katherine, Kockelbergh Hannah, Luo Yang, Guevara Becerra Martha, Vadakethala Katherine, Coy Madeleine, Kabiri Ladan, Barnardo Martin, Dunachie Susanna, Kronsteiner Barbara, Adams Anna, Fowler Darren, Zhang Qian, Fachal Laura, Anderson Carl A, Desoki Rofaida, Vestergaard Marie Vibeke, Larsen Lone, Wyatt Nicola J, Lees Robert D, Mulligan Robert J, Dong Chaonan, Sharip Mohmmed Tauseef, Faustini Siân E, Shields Adrian, Pakpoor Julia, Naz Bushra, Richter Alex, Satsangi Jack, Lamb Christopher A, Parkes Miles, Powrie Fiona, Mentzer Alexander J, Sazonovs Aleksejs, Jess Tine, Klenerman Paul, Travis Simon, Hambleton Sophie, Doffinger Rainer, Uhlig Holm H
Abstract excerpt
BACKGROUND: Neutralizing autoantibodies against interleukin-10 can result in a phenocopy of monogenic defects of interleukin-10 signaling in children and may be associated with inflammatory bowel disease (IBD). The allele HLA-DRB1*01:03 is the strongest genetic risk factor for ulcerative colitis. METHODS: We used a cellular interleukin-10 reporter assay and a confirmatory competitive enzyme-linked immunosorbent...
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