Article
HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn's disease.
Gastroenterology - 1 Sept 2011
Okada Yukinori, Yamazaki Keiko, Umeno Junji, Takahashi Atsushi, Kumasaka Natsuhiko, Ashikawa Kyota, Aoi Tomomi, Takazoe Masakazu, Matsui Toshiyuki, Hirano Atsushi, Matsumoto Takayuki, Kamatani Naoyuki, Nakamura Yusuke, Yamamoto Kazuhiko, Kubo Michiaki
Abstract excerpt
BACKGROUND & AIMS: There are many genetic factors that are associated with both ulcerative colitis (UC) and Crohn's disease (CD). However, genetic factors that have distinct effects on UC and CD have not been examined. METHODS: We performed a comparative genome-wide association study (GWAS) and a replication study using data from 748 patients with UC and 979 with CD, selected from a Japanese population. We...
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