Article
Multi-sampling allows intra-tumoral heterogeneity querying and vulnerability profiling in glioblastoma.
Neuro-oncology - 1 Sept 2026
Garcia Diogo Moniz, Lin Wan-Hsin, Wickland Daniel P, Jessen Erik, Middlebrooks Erik H, Haydu Lauren E, Brooks Mieu, Feathers Ryan W, Kinsella Lindsey, Sereduk Chris, Rosenfeld Steven S, Tran Nhan L, Chaichana Kaisorn L, Anastasiadis Panos Z, Quiñones-Hinojosa Alfredo
Abstract excerpt
BACKGROUND: Glioblastoma (GBM) remains a devastating cancer with limited treatment options, largely due to its heterogeneity. While supramaximal resection has recently provided survival benefits, therapeutic profiling of different tumor compartments, particularly its infiltrative edge remains largely unexplored. METHODS: Here, we leveraged magnetic resonance imaging (MRI)-guided multi-sampling, collecting 2 cores...
Read the complete abstract on PubMedTopics
- Humans
- Glioblastoma
- Brain Neoplasms
- Magnetic Resonance Imaging
- Biomarkers, Tumor