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Article

Investigating The Bidirectional Relationship Between Low Back Pain, Hip Pain, Knee Pain, And Gait Abnormalities: A Mendelian Randomization Study.

Journal of visualized experiments : JoVE - 26 May 2026

Zhou Jun, Xie Xiaoming, Zhang Kuayue, Xia Qiuyu, Zhang Jiarun, Zhang Jiaqi, Xin Zeyin, Yuan Fang, Liu Lu, Li Bin

Abstract excerpt

Gait abnormalities are associated with altered lower-limb biomechanics and functional impairment in musculoskeletal disorders. Although low back pain, hip pain, and knee pain have been linked to impaired gait in observational studies, their causal relationships remain unclear. We conducted a bidirectional Mendelian randomization (MR) study to assess potential causal associations between site-specific pain and...

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PMID: 42296183
DOI: 10.3791/70821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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