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Article

Exploring Causal Correlations Between Depression and Musculoskeletal Disorders: A Bidirectional Mendelian Randomization Study.

Biopsychosocial science and medicine - 1 Jun 2026

Tong Jingyi, Zhu Min, Tan Weijia, Chen Jiajia

Abstract excerpt

OBJECTIVE: Observational studies suggest a strong but poorly understood association between depression and musculoskeletal disorders (MSDs). This study aims to investigate the bidirectional causal relationships between depression and specific MSDs using Mendelian randomization (MR). METHODS: Bidirectional MR used GWAS data from European (n=484,598) and East Asian (n=152,389) populations. Independent SNPs ( p...

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PMID: 42061393
DOI: 10.1097/PSY.0000000000001474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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