Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigating the Causal Relationship Between Physical Activity and Chronic Back Pain: A Bidirectional Two-Sample Mendelian Randomization Study

20 Dec 2021

Abstract excerpt

Background: Recent observational studies have reported a negative association between physical activity and chronic back pain (CBP), but the causality of the association remains unknown. We introduce bidirectional Mendelian randomization (MR) to assess potential causal inference between physical activity and CBP. Materials and Methods: This two-sample MR used independent genetic variants associated with physical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fibromyalgia and Chronic Fatigue Syndrome Research
Share to Genetic Associations and Epidemiology
Share to Genetics and Physical Performance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34987546
DOI: 10.3389/fgene.2021.758639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigating the Causal Relationship Between Physical Activity and Chronic Back Pain: A Bidirectional Two-Sample Mendelian Randomization StudyPMID 34987546Read ↗

Investigating the causal relationship between physical activity and chronic back pain: a bidirectional two-sample Mendelian randomization studySemantic proximity Read ↗

Assessment of causal effects of physical activity on the risk of osteoarthritis: a two-sample Mendelian randomization study.Semantic proximity Read ↗

Evidence of causal effects of blood pressure on back pain and back pain on type II diabetes provided by a bidirectional Mendelian randomization study.Semantic proximity Read ↗

Causal association of physical activity with low back pain, intervertebral disc degeneration and sciatica: a two-sample mendelian randomization analysis studySemantic proximity Read ↗

Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and adiposity.Semantic proximity Read ↗

Causal effects of psychosocial factors on chronic back pain: a bidirectional Mendelian randomisation study.Semantic proximity Read ↗

Causal Effect of Physical Activity on Chronic Obstructive Pulmonary Disease: A Two-Sample Mendelian Randomization StudySemantic proximity Read ↗

Chronic low back pain causal risk factors identified by Mendelian randomization: a cross-sectional cohort analysisSemantic proximity Read ↗

Chronic Low Back Pain Causal Risk Factors Identified by Mendelian Randomization: a Cross-Sectional Cohort AnalysisSemantic proximity Read ↗

Investigating the causal relationship between physical activity and incident knee osteoarthritis: a two-sample Mendelian randomization study.Semantic proximity Read ↗

No Evidence of a Genetic Causal Relationship between Metabolic Syndrome and Low Back Pain: A Two-Sample Mendelian Randomization StudySemantic proximity Read ↗

Causal effect of serum 25-hydroxyvitamin D levels on low back pain: A two-sample mendelian randomization studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.