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Article

Causal Associations of Obesity With the Intervertebral Degeneration, Low Back Pain, and Sciatica: A Two-Sample Mendelian Randomization Study.

Frontiers in endocrinology - 1 Jan 2021

Zhou Jingzhu, Mi Jiarui, Peng Yu, Han Huirong, Liu Zhengye

Abstract excerpt

The role of obesity in the development of dorsopathies is still unclear. In this study, we assessed the associations between body mass index (BMI) and several dorsopathies including intervertebral disc degeneration (IVDD), low back pain (LBP), and sciatica by using the Mendelian randomization method. We also assessed the effect of several obesity-related traits on the same outcomes. Single-nucleotide...

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Identifiers

PMID: 34956075
DOI: 10.3389/fendo.2021.740200
PMCID: PMC8692291

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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