Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.

Development (Cambridge, England) - 1 Feb 1998

Xu X, Weinstein M, Li C, Naski M, Cohen R I, Ornitz D M, Leder P, Deng C

Abstract excerpt

FGFR2 is a membrane-spanning tyrosine kinase that serves as a high affinity receptor for several members of the fibroblast growth factor (FGF) family. To explore functions of FGF/FGFR2 signals in development, we have mutated FGFR2 by deleting the entire immunoglobin-like domain III of the receptor. We showed that murine FGFR2 is essential for chorioallantoic fusion and placenta trophoblast cell proliferation....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Growth Substances

Share to Mice, Knockout

Share to Mutation

Share to Phenotype

Source

Identifiers

PMID: 9435295
DOI: 10.1242/dev.125.4.753

Genes

FGFR2
FGF10
FGF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.PMID 9435295Read ↗

Fgfr2 is required for limb outgrowth and lung-branching morphogenesis.Semantic proximity Read ↗

Roles of FGF receptors in mammalian development and congenital diseases.Semantic proximity Read ↗

Fibroblast growth factor receptor 2 (Fgfr2) plays an important role in eyelid and skin formation and patterning.Semantic proximity Read ↗

Fibroblast growth factor receptor two (FGFR2) regulates uterine epithelial integrity and fertility in mice.Semantic proximity Read ↗

FGF signaling regulates development by processes beyond canonical pathways.Semantic proximity Read ↗

FGFs, their receptors, and human limb malformations: clinical and molecular correlations.Semantic proximity Read ↗

Clarifying Frizzled 2 function in development through genetically validated mouse models.Semantic proximity Read ↗

Fgfr1 regulates development through the combinatorial use of signaling proteins.Semantic proximity Read ↗

Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development.Semantic proximity Read ↗

EGFR confers exquisite specificity of Wnt9a-Fzd9b signaling in hematopoietic stem cell developmentSemantic proximity Read ↗

FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus.Semantic proximity Read ↗

Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.