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Article

FGF signaling regulates development by processes beyond canonical pathways.

Genes & development - 1 Dec 2020

Ray Ayan T, Mazot Pierre, Brewer J Richard, Catela Catarina, Dinsmore Colin J, Soriano Philippe

Abstract excerpt

FGFs are key developmental regulators that engage a signal transduction cascade through receptor tyrosine kinases, prominently engaging ERK1/2 but also other pathways. However, it remains unknown whether all FGF activities depend on this canonical signal transduction cascade. To address this question, we generated allelic series of knock-in Fgfr1 and Fgfr2 mouse strains, carrying point mutations that disrupt...

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Identifiers

PMID: 33184218
DOI: 10.1101/gad.342956.120
PMCID: PMC7706708

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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