Article
EGFR confers exquisite specificity of Wnt9a-Fzd9b signaling in hematopoietic stem cell development
2018-08-07
Abstract excerpt
<h4>Summary</h4> The mechanisms of Wnt-Frizzled (Fzd) signaling selectivity and their biological implications remain unclear. We demonstrate for the first time that the epidermal growth factor receptor (EGFR) is required as a co-factor for Wnt signaling. Using genetic studies in zebrafish, paired with in vitro cell biology and biochemistry, we have determined that Fzd9b signals specifically with Wnt9a in vivo a...
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Identifiers and source
- Literature Corpus work
- ed08e16f-fddb-5b9b-a15e-38038f02f201
- DOI
- 10.1101/387043