Article

Distributed genetic architecture across the hippocampal formation implies common neuropathology across major brain disorders

2021-08-24

Abstract excerpt

Despite its major role in complex human behaviours across the lifespan, including memory formation and decline, navigation and emotions, much of the genetic architecture of the hippocampal formation is currently unexplored. Here, through multivariate genome-wide association analysis in volumetric data from 35,411 individuals, we revealed 173 unique genetic loci with distributed associations across the hippocampal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cdbff61d-ca48-512d-8dd3-034fd80c1366
DOI: 10.1101/2021.08.18.21262223

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distributed genetic architecture across the hippocampal formation implies common neuropathology across major brain disordersDOI 10.1101/2021.08.18.21262223Read

Distributed genetic architecture across the hippocampal formation implies common neuropathology across brain disorders.Semantic proximity Read

Genetic architectures of the human hippocampus and those involved in neuropsychiatric traits.Semantic proximity Read

Novel genetic loci associated with hippocampal volume.Semantic proximity Read

Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes.Semantic proximity Read

Brain scans from 21297 individuals reveal the genetic architecture of hippocampal subfield volumesSemantic proximity Read

Heritability of hippocampal functional and microstructural organisationSemantic proximity Read

Shared genetic architecture between Alzheimer's disease and brain morphology.Semantic proximity Read

Structural Neuroimaging Genetics Interactions in Alzheimer's Disease.Semantic proximity Read

A pattern of continuity from health to disease in neuropsychiatric genetic risk affecting brain morphologySemantic proximity Read

The genetic architecture of human brainstem structures and their involvement in common brain disordersSemantic proximity Read

Genome-wide analysis of subcortical aging identifies a spatially structured pattern of genetic associationsSemantic proximity Read

Associations between Alzheimer’s disease polygenic risk scores and hippocampal subfield volumes in 17,161 UK Biobank participantsSemantic proximity Read