Article
AMPK-mediated prevention of vascular dysfunction with metformin: Experimental and population-based evidence.
British journal of pharmacology - 1 Sept 2026
Mohammadi Jouabadi Soroush, Jüttner Annika A, Claringbould Annique, de Vries Rene, Garrelds Ingrid M, Musterd-Bhaggoe Usha, Stricker Bruno H, Kavousi Maryam, Danser A H Jan, Ahmadizar Fariba, Roks Anton J M
Abstract excerpt
BACKGROUND AND PURPOSE: Metformin is increasingly recognised for its vasculoprotective effects, primarily through activation of AMP-activated protein kinase (AMPK). We combined population-based genetic epidemiology, with an ex vivo vascular model, to investigate the beneficial vascular effects of AMPK activation by metformin. EXPERIMENTAL APPROACH: We used genetically proxied AMPK activation (GP-AMPK), based on...
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