Article
A PPARα promoter variant impairs ERR-dependent transactivation and decreases mortality after acute coronary ischemia in patients with diabetes.
PloS one - 3 Sept 2010
Cresci Sharon, Huss Janice M, Beitelshees Amber L, Jones Philip G, Minton Matt R, Dorn Gerald W, Kelly Daniel P, Spertus John A, McLeod Howard L
Abstract excerpt
Activation of peroxisome proliferator-activated receptor alpha (PPARα) occurs in animal models of diabetes (DM) and is implicated in pathological responses to myocardial ischemia. Using bioinformatics, we identified a single nucleotide polymorphism (SNP) in the PPARα gene promoter (PPARA -54,642 G>A; rs135561) that altered the consensus sequence for a nuclear receptor binding site. Electrophoretic mobility shift...
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