Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pleiotropic Benefits of Metformin: Macrophage Targeting Its Anti-inflammatory Mechanisms

16 May 2015

Abstract excerpt

Metformin is a biguanide family member used in the treatment of type 2 diabetes and one of the most widely prescribed antidiabetes drugs. This drug increases the peripheral uptake of glucose, decreases hepatic glucose production, and reduces insulin resistance in liver and skeletal muscle. The exact molecular mechanisms responsible for its effect on glucose homeostasis are still not completely understood but may...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Immune cells in cancer
Share to Metabolism, Diabetes, and Cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25999535
DOI: 10.2337/db15-0090

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pleiotropic Benefits of Metformin: Macrophage Targeting Its Anti-inflammatory MechanismsPMID 25999535Read ↗

Metformin affects macrophages' phenotype and improves the activity of glutathione peroxidase, superoxide dismutase, catalase and decreases malondialdehyde concentration in a partially AMPK-independent manner in LPS-stimulated human monocytes/macrophages.Semantic proximity Read ↗

Nonglycemic Effects of SGLT2 Inhibitors: Focus on Inflammation and MacrophagesSemantic proximity Read ↗

Exenatide and metformin express their anti-inflammatory effects on human monocytes/macrophages by the attenuation of MAPKs and NFκB signaling.Semantic proximity Read ↗

Anti-tumor activity of metformin: from metabolic and epigenetic perspectivesSemantic proximity Read ↗

Cellular and Molecular Mechanisms of Metformin ActionSemantic proximity Read ↗

Metformin: an old drug with potential therapeutic function in antitumorSemantic proximity Read ↗

Metformin ameliorates olanzapine-induced insulin resistance via suppressing macrophage infiltration and inflammatory responses in rats.Semantic proximity Read ↗

Molecular mechanism of action of metformin: old or new insights?Semantic proximity Read ↗

Metformin directly suppresses atherosclerosis in normoglycaemic mice via haematopoietic adenosine monophosphate-activated protein kinase.Semantic proximity Read ↗

AMPK-mediated prevention of vascular dysfunction with metformin: Experimental and population-based evidence.Semantic proximity Read ↗

Pharmacological AMP-activated protein kinase activation suppresses low glucose-dependent macrophage migration inhibitory factor release from macrophagesSemantic proximity Read ↗

Metformin in combination with genistein ameliorates skeletal muscle inflammation in high-fat diet fed c57BL/6 mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.