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Adenosine 5'monophosphate-activated protein kinase activation reduces the risks of psoriasis and its comorbidities: a Mendelian randomization study in the UK Biobank.

Rheumatology (Oxford, England) - 3 May 2024

Xiao Yi, Jing Danrong, Zhou Guowei, Tang Zhenwei, Peng Cong, Kuang Yehong, Zhu Wu, Chen Xiang, Liu Hong, Shen Minxue

Abstract excerpt

OBJECTIVE: Whether metformin and its adenosine 5'monophosphate-activated protein kinase (AMPK) activation protect from psoriasis risk is unconcluded. We investigated the effect of AMPK, a pharmacological target of metformin, on the risk of psoriasis and its comorbidities and mortality among participants in the UK Biobank (UKB). METHODS: To avoid immortal time biases in pharmacoepidemiologic studies, Mendelian...

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PMID: 37672020
DOI: 10.1093/rheumatology/kead462

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