MIXPRS enables multi-population and multi-method polygenic risk scores using summary statistics.

Abstract excerpt

Many multi-population polygenic risk score (PRS) methods have been proposed to improve prediction in underrepresented populations; however, no single method performs best across all scenarios. Although integrating PRSs across multiple methods and populations may improve prediction, this approach is often limited by the need for individual-level tuning data. Here we introduce MIXPRS, a robust framework based on...

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