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Article

A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15.

Structure (London, England : 1993) - 7 Mar 2017

Powers Robert E, Gaudet Rachelle, Sotomayor Marcos

Abstract excerpt

Tip links of the inner ear are protein filaments essential for hearing and balance. Two atypical cadherins, cadherin-23 and protocadherin-15, interact in a Ca2+-dependent manner to form tip links. The largely unknown structure and mechanics of these proteins are integral to understanding how tip links pull on ion channels to initiate sensory perception. Protocadherin-15 has 11 extracellular cadherin (EC) repeats....

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Amino Acid Motifs
Binding Sites
Cadherin Related Proteins
Cadherins
Calcium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Molecular

Protein Structure, Tertiary

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Identifiers

PMID: 28238533
DOI: 10.1016/j.str.2017.01.014
PMCID: PMC5363953

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Click a neighbor to travelStep 1 · 12 closest

A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15.PMID 28238533Read ↗

Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction.Semantic proximity Read ↗

Nanomechanics of wild-type and mutant dimers of the inner-ear tip-link protein protocadherin 15.Semantic proximity Read ↗

Elasticity and Thermal Stability are Key Determinants of Hearing Rescue by Mini-Protocadherin-15 ProteinsSemantic proximity Read ↗

Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells.Semantic proximity Read ↗

Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members.Semantic proximity Read ↗

Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15.Semantic proximity Read ↗

Giant cadherins Fat and Dachsous self-bend to organize properly spaced intercellular junctions.Semantic proximity Read ↗

Tip links in hair cells: molecular composition and role in hearing lossSemantic proximity Read ↗

Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells.Semantic proximity Read ↗

Weakening of interaction networks with aging in tip-link protein induces hearing loss.Semantic proximity Read ↗

The Dynamic Strength of the Hair-Cell Tip Link Reveals Mechanisms of Hearing and DeafnessSemantic proximity Read ↗

The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells.Semantic proximity Read ↗

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