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Article

The effect of SGLT2 inhibition on immune cells and transplant rejection/failure: A drug-targeted mendelian randomization study.

Transplant immunology - 1 Jun 2026

Xiao Hanyu, Zeng Xiang, Pang Qidan, Chen Hong, Lai Suhe

Abstract excerpt

BACKGROUND: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) yield additional cardiorenal benefits beyond glycemic control. Emerging evidence suggests that SGLT2i have potential benefits in organ transplantation, though causal relationships remain unclear. This study aimed to investigate the causal effect of SGLT2 inhibition on transplant rejection and failure (TRF) and the mediating role of immune cell...

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Share to CD4 gene
Share to Glycated Hemoglobin
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Organ Transplantation

Share to Polymorphism, Single Nucleotide

Share to T-Lymphocytes, Regulatory

Source

Identifiers

PMID: 41941971
DOI: 10.1016/j.trim.2026.102385

Genes

CD4
SLC5A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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